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CCL2 Protein

CCL2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Catalog No. ABIN7320483
  • Target See all CCL2 Proteins
    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
    Protein Type
    Recombinant
    Origin
    • 16
    • 13
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Source
    • 34
    • 10
    • 9
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purpose
    Recombinant Mouse CCL2/MCP-1 Protein
    Sequence
    Gln24-Arg96
    Characteristics
    Recombinant Mouse C-C motif Chemokine 2 is produced by our E.coli expression system and the target gene encoding Gln24-Arg96 is expressed.
    Purity
    > 95 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product CCL2 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
    Alternative Name
    CCL2/MCP-1 (CCL2 Products)
    Background

    Background: C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82 % amino acid (aa) identity with rat CCL2 over the entire sequence, and 58 %, 56 %, 55 %, 53 % and 53 % aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.

    Synonym: C-C motif chemokine 2, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1,Platelet-derived growth factor-inducible protein JE, Small-inducible cytokine A2, Ccl2, Je, Mcp1, Scya2

    Molecular Weight
    8.5 kDa
    UniProt
    P10148
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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