CDC37 Protein

Catalog No. ABIN7195023

Product Details

Target: CDC37 (Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37))

Protein Type: Recombinant

Origin: Mouse

Source: Baculovirus infected Insect Cells

Purpose: Recombinant Mouse CDC37/CDC37A Protein

Sequence: Met1-Ala379

Characteristics: A DNA sequence encoding the mouse CDC37 (Q61081) (Met1-Ala379) was expressed with two additional amino acids (Gly & Pro) at the N-terminus.

Purity: > 85 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CDC37 (Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37))

Alternative Name: CDC37/CDC37A (CDC37 Products)

Synonyms: CG12019 Protein, CPDR-1 Protein, CPDR-2 Protein, DROCPDR Protein, Dmel\\CG12019 Protein, E(sev)3B Protein, cdc37 Protein, Afu4g10010 Protein, P50CDC37 Protein, p50 Protein, p50Cdc37 Protein, CG12019 gene product from transcript CG12019-RA Protein, cell division cycle 37 homolog Protein, Hsp90 co-chaperone Cdc37 Protein, Cdc37p Protein, cell division cycle 37 Protein, Cdc37 Protein, cdc37 Protein, AFUA_4G10010 Protein, CDC37 Protein

Background:

Background: CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.

Synonym: p50,p50Cdc37

Molecular Weight: 44.7 kDa

UniProt: Q61081