CD59a Protein (CD59A) (His tag)
-
- Target See all CD59a (CD59A) Proteins
- CD59a (CD59A)
- Protein Type
- Recombinant
- Origin
- Mouse
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CD59a protein is labelled with His tag.
- Purpose
- Recombinant Mouse CD59a/MAC-IP Protein (His Tag)
- Sequence
- Met 1-Lys 95
- Characteristics
- A DNA sequence encoding the mouse CD59a (O55186) (Met 1-Lys 95), without the pro peptide, was fused with a C-terminal polyhistidine tag.
- Purity
- > 92 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product CD59A Protein
-
CD59a (CD59A) (AA 24-96) protein (Fc Tag)
CD59A Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- Target
- CD59a (CD59A)
- Alternative Name
- CD59a/MAC-IP (CD59A Products)
- Synonyms
- AA987121 Protein, Cd59 Protein, protectin Protein, CD59a antigen Protein, Cd59a Protein
- Background
-
Background: Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins.It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor, it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.
Synonym: AA987121,Cd59,protectin,RP24-297H17.1
- Molecular Weight
- 9.7 kDa
- UniProt
- O55186
-
