DCL1 Protein (Fc Tag)

Catalog No. ABIN7320182

Product Details

Target: DCL1 (CD302) (CD302)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This DCL1 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse CD302/CLEC13A Protein (Fc Tag)

Sequence: Met 1-His 156

Characteristics: A DNA sequence encoding the extracellular domain of mouse CD302 isoform 2 (Q9DCG2-2) (Met 1-His 156) was fused with the Fc region of human IgG1 at the C-terminus.

Purity: > 93 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: DCL1 (CD302) (CD302)

Alternative Name: CD302/CLEC13A (CD302 Products)

Synonyms: BIMLEC Protein, CLEC13A Protein, DCL-1 Protein, DCL1 Protein, RGD1307606 Protein, MGC154447 Protein, 1110055L24Rik Protein, AI159627 Protein, CD302 molecule Protein, CD302 molecule S homeolog Protein, CD302 antigen Protein, CD302 Protein, Cd302 Protein, cd302.S Protein

Background:

Background: CD302/CLEC13A (C-type lectin domain family 13 member A), also known as C-type lectin receptor DCL-1, is a type I transmembrane C-type lectin DCL-1/CD302. DCL-1 protein was highly conserved among the human, mouse, and rat orthologs. DCL-1 ectodomain contains only one CRD, whereas other type I transmembrane C-type lectins contain more than one domain (e.g. selectins and MMR). DCL-1 CP contains several putative motifs, including a Tyr-based internalization, a cluster of acidic amino acids, and Ser and Tyr phosphorylation motifs, suggesting that DCL-1 CP mediates not only endocytosis and late endosome targeting but also signaling. DCL-1 may be another cell/matrix adhesion receptor integrated in cell adhesion complexes and that DCL-1 dysfunction may affect APC adhesion and migration, causing suppression of APC function.

Synonym: 1110055L24Rik,AI159627

Molecular Weight: 42.6 kDa

Pathways: Regulation of Actin Filament Polymerization