CD276 Protein (CD276) (Fc Tag)
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- Target See all CD276 Proteins
- CD276
- Protein Type
- Recombinant
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Origin
- Cynomolgus
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Source
- Human Cells
- Purification tag / Conjugate
- This CD276 protein is labelled with Fc Tag.
- Purpose
- Recombinant Cynomolgus B7-H3/CD276 Protein (Fc Tag)
- Sequence
- Leu29-Glu465
- Characteristics
- Recombinant Cynomolgus CD276 Molecule is produced by our Mammalian expression system and the target gene encoding Leu29-Glu465 is expressed with a Fc tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CD276 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CD276
- Alternative Name
- B7-H3/CD276 (CD276 Products)
- Background
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Background: CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20-27 % amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.
Synonym: CD276 antigen, CD276, B7 homolog 3, B7-H3,CD276
- Molecular Weight
- 74 kDa
- NCBI Accession
- XP_015308534
- Pathways
- Cancer Immune Checkpoints
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