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CD209b Antigen (CD209B) protein (His tag)

CD209B Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Catalog No. ABIN7320261
  • Target See all CD209b Antigen (CD209B) Proteins
    CD209b Antigen (CD209B)
    Protein Type
    Recombinant
    Origin
    Mouse
    Source
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    His tag
    Purpose
    Recombinant Mouse CD209B/DC-SIGNR1 Protein (His Tag)
    Sequence
    Gln 74-Gly 325
    Characteristics
    A DNA sequence encoding the extracellular domain of mouse CD209B isoform 1 (NP_081248.2) (Gln 74-Gly 325) was fused with a polyhistidine tag at the N-terminus.
    Purity
    > 95 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CD209b Antigen (CD209B)
    Alternative Name
    CD209B/DC-SIGNR1 (CD209B Products)
    Synonyms
    1810030I22Rik Protein, OtB7 Protein, SIGNR1 Protein, mSIGNR1 Protein, CD209b antigen Protein, Cd209b Protein
    Background

    Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD209b, also known as SIGNR1, is a C-type lectin receptor. CD209b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD209b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD209b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.

    Synonym: 1810030I22Rik,DC-SIGNR1,mSIGNR1,OtB7,SIGNR1

    Molecular Weight
    31.4 kDa
    NCBI Accession
    NP_081248
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