CD2 Protein (CD2) (His tag)

Catalog No. ABIN7320241

Product Details

Target: CD2

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This CD2 protein is labelled with His tag.

Purpose: Recombinant Mouse CD2 Protein (His Tag)

Sequence: Met 1-Ser 203

Characteristics: A DNA sequence encoding the extracellular domain of mouse CD2 (NP_038514.1) (Met 1-Ser 203) was expressed, with a polyhistidine tag at the C-terminus.

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD2

Alternative Name: CD2 (CD2 Products)

Synonyms: CD2 Protein, LFA-2 Protein, Ly-37 Protein, Ly37 Protein, SRBC Protein, T11 Protein, CD2R Protein, LFA2 Protein, OX-34 Protein, OX34 Protein, CD2 molecule Protein, CD2 antigen Protein, Cd2 molecule Protein, CD2 Protein, Cd2 Protein

Background:

Background: T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: LFA-2;Ly-37;Ly37

Molecular Weight: 22 kDa

NCBI Accession: NP_038514