CD164 Protein (CD164) (His tag)

Catalog No. ABIN7317390

Product Details

Target: CD164

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CD164 protein is labelled with His tag.

Purpose: Recombinant Human CD164/Endolyn Protein (His Tag)

Sequence: Met 1-Asp 162

Characteristics: A DNA sequence encoding the human CD164 (Q04900-1) extracellular domain (Met 1-Asp 162) was fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CD164

Alternative Name: CD164/Endolyn (CD164 Products)

Synonyms: MGC-24 Protein, MUC-24 Protein, endolyn Protein, CD164 Protein, MGC-24v Protein, fb75f06 Protein, fj87f10 Protein, wu:fb75f06 Protein, wu:fj87f10 Protein, si:ch211-51a19.2 Protein, A115 Protein, A24 Protein, AA589639 Protein, AW540279 Protein, MSSP Protein, CD164 molecule Protein, CD164 molecule, sialomucin Protein, CD164 antigen Protein, CD164 Protein, Cd164 Protein, cd164 Protein

Background:

Background: Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a novel 80- to 90-kD mucin-like molecule expressed by human CD34+ hematopoietic progenitor cells. Isoform 1 and isoform 3 of CD164 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 of CD164 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells. CD164 belongs to the CD164 family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. CD164 may play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. CD164 promotes myogenesis by enhancing CXCR4-dependent cell motility. This protein positively regulates myoblast migration and promotes myoblast fusion into myotubes. CD164 may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to bone marrow stroma and by negatively regulating CD34+hematopoietic progenitor cell growth.

Synonym: endolyn,MGC-24,MUC-24

Molecular Weight: 15.9 kDa