Cathepsin D Protein (CTSD) (His tag)

Catalog No. ABIN7320739

Product Details

Target: Cathepsin D (CTSD)

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This Cathepsin D protein is labelled with His tag.

Purpose: Recombinant Mouse Cathepsin D/CTSD Protein (His Tag)

Sequence: Ile21-Leu410

Characteristics: Recombinant Mouse Cathepsin D is produced by our Mammalian expression system and the target gene encoding Ile21-Leu410 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM MES,150 mM NaCl, pH 5.5.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Cathepsin D (CTSD)

Alternative Name: Cathepsin D/CTSD (CTSD Products)

Synonyms: catD Protein, fb93e11 Protein, fj17b09 Protein, wu:fb93e11 Protein, wu:fj17b09 Protein, LOC398557 Protein, Cathd Protein, CatD Protein, LOC100136761 Protein, CTSD Protein, DKFZp469J0315 Protein, DDBDRAFT_0205785 Protein, DDBDRAFT_0215012 Protein, DDB_0205785 Protein, DDB_0215012 Protein, CLN10 Protein, CPSD Protein, CD Protein, cathepsin D Protein, cathepsin D S homeolog Protein, lysosomal aspartic protease Protein, cathepsin D-like Protein, ctsd Protein, LOC398557 Protein, ctsd.S Protein, CatD Protein, LOC5567565 Protein, LOC100136761 Protein, CTSD Protein, Cathd Protein, ctsD Protein, catd Protein, Ctsd Protein, LOC443060 Protein

Background:

Background: CTSD localizes to the lysosome and consists of a light chain and a heavy chain. CTSD is expressed in epithelial cells as well as in macrophages.CTSD is a lysosomal aspartyl protease that depends critically on protonation of its active site Asp residue and gets activated at pH 5 in endosome of hepatocytes. It has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix and xonnective tissue. In addition, CTSD has been used as a breast cancer tumor marker.

Synonym: Cathepsin D, CTSD,CPSD

Molecular Weight: 43.9 kDa

NCBI Accession: NP_034113

Pathways: Peptide Hormone Metabolism