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Cathepsin D Protein (CTSD) (His tag)

CTSD Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7318253
  • Target See all Cathepsin D (CTSD) Proteins
    Cathepsin D (CTSD)
    Protein Type
    Recombinant
    Origin
    • 10
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 12
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This Cathepsin D protein is labelled with His tag.
    Purpose
    Recombinant Human Cathepsin D/CTSD Protein (His Tag)
    Sequence
    Leu21-Leu412
    Characteristics
    Recombinant Human Cathepsin D is produced by our Mammalian expression system and the target gene encoding Leu21-Leu412 is expressed with a 6His tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product CTSD Protein
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5.
    Storage
    -20 °C
    Storage Comment
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    Cathepsin D (CTSD)
    Alternative Name
    Cathepsin D/CTSD (CTSD Products)
    Synonyms
    catD Protein, fb93e11 Protein, fj17b09 Protein, wu:fb93e11 Protein, wu:fj17b09 Protein, LOC398557 Protein, Cathd Protein, CatD Protein, LOC100136761 Protein, CTSD Protein, DKFZp469J0315 Protein, DDBDRAFT_0205785 Protein, DDBDRAFT_0215012 Protein, DDB_0205785 Protein, DDB_0215012 Protein, CLN10 Protein, CPSD Protein, CD Protein, cathepsin D Protein, cathepsin D S homeolog Protein, lysosomal aspartic protease Protein, cathepsin D-like Protein, ctsd Protein, LOC398557 Protein, ctsd.S Protein, CatD Protein, LOC5567565 Protein, LOC100136761 Protein, CTSD Protein, Cathd Protein, ctsD Protein, catd Protein, Ctsd Protein, LOC443060 Protein
    Background

    Background: The protein acid protease active in intracellular protein breakdown and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. It is specificity similar to, but narrower than, that of pepsin A and it does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. It consists of a light chain and a heavy chain and expressed in the aorta extrcellular space. The Val-58 allele is significantly overrepresented in demented patients (11.8 % ) compared with non-demented controls (4.9 %). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.It belongs to the peptidase A1 family

    Synonym: Cathepsin D, CTSD,CLN10,CPSD,HEL-S-130P

    Molecular Weight
    43.8 kDa
    UniProt
    P07339
    Pathways
    Peptide Hormone Metabolism
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