Cathepsin D Protein (CTSD) (His tag)

Catalog No. ABIN7318253

Product Details

Target: Cathepsin D (CTSD)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This Cathepsin D protein is labelled with His tag.

Purpose: Recombinant Human Cathepsin D/CTSD Protein (His Tag)

Sequence: Leu21-Leu412

Characteristics: Recombinant Human Cathepsin D is produced by our Mammalian expression system and the target gene encoding Leu21-Leu412 is expressed with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: Cathepsin D (CTSD)

Alternative Name: Cathepsin D/CTSD (CTSD Products)

Background:

Background: The protein acid protease active in intracellular protein breakdown and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. It is specificity similar to, but narrower than, that of pepsin A and it does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. It consists of a light chain and a heavy chain and expressed in the aorta extrcellular space. The Val-58 allele is significantly overrepresented in demented patients (11.8 % ) compared with non-demented controls (4.9 %). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.It belongs to the peptidase A1 family

Synonym: Cathepsin D, CTSD,CLN10,CPSD,HEL-S-130P

Molecular Weight: 43.8 kDa

UniProt: P07339

Pathways: Peptide Hormone Metabolism