CALML5 Protein (GST tag,His tag)
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- Target See all CALML5 Proteins
- CALML5 (Calmodulin-Like 5 (CALML5))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CALML5 protein is labelled with GST tag,His tag.
- Purpose
- Recombinant Human CALML5/CLSP Protein (His & GST Tag)
- Sequence
- Met 1-Glu 146
- Characteristics
- A DNA sequence encoding the human CALML5 (AAH39172.1) (Met 1-Glu 146) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Purity
- > 92 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CALML5 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 1 mM DTT, 0.5 mM GSH, 10 % glycerol, pH 7.8
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CALML5 (Calmodulin-Like 5 (CALML5))
- Alternative Name
- CALML5/CLSP (CALML5 Products)
- Synonyms
- CALML5 Protein, CLSP Protein, F14B2.33 Protein, multicopy suppressors of snf4 deficiency in yeast 3 Protein, calmodulin like 5 Protein, calmodulin-like 5 Protein, Calcium-binding EF-hand family protein Protein, CALML5 Protein, MSS3 Protein
- Background
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Background: Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains four EF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily and a component of epithelial tight junction. CAR functions as a primary receptor for coxsackievirus B and adenovirus (Ad) infection. CALML5 / CLSP is closely related to CAR. The structure and dynamics of human calmodulin-like skin protein CALML5 / CLSP have been characterized by NMR spectroscopy. The mobility of CALML5 / CLSP has been found to be different for the N-terminal and C-terminal domains. The N-terminal domain is characterized by four stable helices, which experience large fluctuations. This is shown to be due to mutations in the hydrophobic core. The overall N-terminal domain behavior is similar both in the full-length protein and in the isolated domain.
Synonym: CLSP
- Molecular Weight
- 44.2 kDa
- Pathways
- Phototransduction
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