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Cadherin 12 Protein (His tag)

Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7317919
  • Target See all Cadherin 12 Proteins
    Cadherin 12
    Protein Type
    Recombinant
    Origin
    Human
    Source
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Cadherin 12 protein is labelled with His tag.
    Purpose
    Recombinant Human Cadherin-12/CDH12 Protein (His Tag)
    Sequence
    Met 1-Ala 605
    Characteristics
    A DNA sequence encoding the pro form of human CDH12 (NP_001783.2) extracellular domain (Met 1-Ala 605) was fused with a polyhistidine tag at the C-terminus.
    Purity
    > 80 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
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    Discover our top product Cadherin 12 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 50 mM sodium citrate, 50 mM NaCl, 2 mM CaCl2, pH 6.0
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Cadherin 12
    Alternative Name
    Cadherin-12/CDH12 (Cadherin 12 Products)
    Synonyms
    CDHB Protein, Cdhb Protein, RGD1566350 Protein, cdh12 Protein, cadherin 12 Protein, cadherin-12 Protein, CDH12 Protein, Cdh12 Protein, LOC570372 Protein
    Background

    Background: Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subtypes at synapses indicate that individual cadherin subtypes play their own unique role to regulate synaptic activities. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. Cadherin-12 also known as CDH12, is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherin-12 appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

    Synonym: CDHB

    Molecular Weight
    66 kDa
    NCBI Accession
    NP_001783
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