CRP Protein (His tag)

Catalog No. ABIN7194463

Product Details

Target: CRP (C-Reactive Protein (CRP))

Protein Type: Recombinant

Origin: Rat

Source: HEK-293 Cells

Purification tag / Conjugate: This CRP protein is labelled with His tag.

Purpose: Recombinant Rat CRP/C-Reactive Protein (His Tag)

Sequence: Met 1-Ser 230

Characteristics: A DNA sequence encoding the rat CRP (NP_058792.1) extracellular domain (Met 1-Ser 230) was fused with a polyhistidine tag at the C-terminus.

Purity: > 97 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: CRP (C-Reactive Protein (CRP))

Alternative Name: CRP/C-Reactive (CRP Products)

Synonyms: PTX1 Protein, crp Protein, AI255847 Protein, Aa1249 Protein, Ab1-341 Protein, Ab2-196 Protein, Ac1-114 Protein, Ac1262 Protein, Ac2-069 Protein, Ba2-693 Protein, APCS Protein, 0610010I23Rik Protein, AW743261 Protein, C77570 Protein, CRP2 Protein, CRP4 Protein, Crp Protein, ESP1 Protein, Hlp Protein, CRP5.1 Protein, zgc:152809 Protein, C-reactive protein Protein, C-reactive protein, pentraxin-related Protein, c-reactive protein, pentraxin-related Protein, cysteine rich protein 2 Protein, CRP Protein, crp Protein, Crp Protein, Crip2 Protein, LOC776376 Protein

Background:

Background: C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.

Synonym: Aa1249,Ab1-341,Ab2-196,Ac1-114,Ac1262,Ac2-069,Ba2-693

Molecular Weight: 24.6 kDa

NCBI Accession: NP_058792

Pathways: Carbohydrate Homeostasis