BNIP3L/NIX Protein

Catalog No. ABIN7317369

Product Details

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purpose: Recombinant Human BNIP3L Protein

Sequence: Ser 2-Lys 187

Characteristics: A DNA sequence encoding the human BNIP3L (NP_004322.1) (Ser 2-Lys 187) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.

Purity: > 88 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 150 mM NaCl, 1 mM DTT, pH 8.0

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Alternative Name: BNIP3L (BNIP3L Products)

Synonyms: BNIP3a Protein, NIX Protein, NIP3 Protein, Nix Protein, Nip3 Protein, C86132 Protein, D14Ertd719e Protein, Nip3L Protein, bnip3l Protein, nip3 Protein, zgc:110478 Protein, bnip3l2 Protein, wu:fb52b03 Protein, wu:fc02h04 Protein, BCL2 interacting protein 3 like Protein, BCL2 interacting protein 3 Protein, BCL2/adenovirus E1B interacting protein 3 Protein, BCL2/adenovirus E1B interacting protein 3-like Protein, BCL2/adenovirus E1B interacting protein 3-like b Protein, BCL2/adenovirus E1B interacting protein 3-like a Protein, BNIP3L Protein, BNIP3 Protein, Bnip3l Protein, Bnip3 Protein, bnip3lb Protein, bnip3la Protein

Background:

Background: The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to the endoplasmic reticulum and Golgi apparatus of wild-type newborn mouse lenses and is contained within mitochondria, endoplasmic reticulum and Golgi apparatus isolated from adult mouse liver. As the cells become packed with keratin bundles, Bnip3L expression triggers mitophagy to rid the cells of the last remaining 'living' characteristic, thus completing the march from 'living' to 'dead' within the hair follicle. during retinal development tissue hypoxia triggers HIF1A/HIF-1 stabilization, resulting in increased expression of the mitophagy receptor BNIP3L/NIX. BNIP3L-dependent mitophagy results in a metabolic shift toward glycolysis essential for RGC neurogenesis. BNIP3L could be a potential therapeutic target for ischemic stroke

Synonym: BNIP3a,NIX

Molecular Weight: 20.4 kDa

Pathways: Autophagy