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APEX1 Protein

APEX1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7318176
  • Target See all APEX1 Proteins
    APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
    Protein Type
    Recombinant
    Origin
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 9
    • 7
    • 2
    • 2
    Escherichia coli (E. coli)
    Purpose
    Recombinant Human APE1/APE Protein
    Sequence
    Pro2-Leu318
    Characteristics
    Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product APEX1 Protein
  • Restrictions
    For Research Use only
  • Format
    Frozen, Liquid
    Buffer
    Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 100 mM KCl, 50 % Glycerol, pH 7.4.
    Storage
    -20 °C
    Storage Comment
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
    Alternative Name
    APE1/APE (APEX1 Products)
    Synonyms
    apex1 Protein, MGC76280 Protein, MGC79645 Protein, MGC78928 Protein, APE Protein, APE1 Protein, APEN Protein, APEX Protein, APX Protein, HAP1 Protein, REF1 Protein, Apex Protein, REF-1 Protein, BAP1 Protein, apex1a Protein, hm:zehn1532 Protein, wu:fc13d11 Protein, zgc:66204 Protein, Ref-1 Protein, apurinic/apyrimidinic endodeoxyribonuclease 1 Protein, APEX nuclease (multifunctional DNA repair enzyme) 1 Protein, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog Protein, DNA-(apurinic or apyrimidinic site) lyase Protein, apurinic/apyrimidinic endonuclease 1 Protein, APEX1 Protein, apex1 Protein, apex1.L Protein, CNG03640 Protein, CNH01280 Protein, nth Protein, Spirs_4119 Protein, Palpr_0103 Protein, Apex1 Protein
    Background

    Background: Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

    Synonym: DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-Apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1REF-1, Redox Factor-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1

    Molecular Weight
    35.6 kDa
    UniProt
    P27695
    Pathways
    DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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