TLR3 Protein (Fc Tag)
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- Target See all TLR3 Proteins
- TLR3 (Toll-Like Receptor 3 (TLR3))
- Protein Type
- Recombinant
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TLR3 protein is labelled with Fc Tag.
- Purpose
- Mouse TLR3 / CD283 Protein, Fc Tag (MALS verified)
- Sequence
- Thr 26 - Leu 705
- Characteristics
- Human TLR3, Fc Tag (TL3-M5255) is expressed from human 293 cells (HEK293). It contains AA Thr 26 - Leu 705 (Accession # Q99MB1-1).
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Grade
- MALS verified
- Top Product
- Discover our top product TLR3 Protein
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Toll-Like Receptor 3 (TLR3) (AA 23-703) protein (His tag)
TLR3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Toll-Like Receptor 3 (TLR3) (AA 31-711) protein (His tag)TLR3 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Toll-Like Receptor 3 (TLR3) (AA 25-705) protein (His tag)TLR3 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Toll-Like Receptor 3 (TLR3) (AA 601-700) protein (GST tag)TLR3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Toll-Like Receptor 3 (TLR3) (AA 23-703) protein (His tag,Biotin)TLR3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Toll-Like Receptor 3 (TLR3) (AA 28-80) protein (Fc Tag)TLR3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Toll-Like Receptor 3 (TLR3) (AA 28-80) protein (mFc Tag)TLR3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- Application Notes
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 103.7 kDa. The protein migrates as kDa under reducing (R) condition due to glycosylation.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target
- TLR3 (Toll-Like Receptor 3 (TLR3))
- Alternative Name
- TLR3 / CD283 (TLR3 Products)
- Synonyms
- CD283 Protein, IIAE2 Protein, AI957183 Protein, zgc:123006 Protein, toll like receptor 3 Protein, toll-like receptor 3 Protein, TLR3 Protein, Tlr3 Protein, tlr3 Protein
- Background
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Synonyms: TLR3,CD283,IIAE2,
Description: Toll-like receptor 3 (TLR3) is also known as CD283, which belongs to the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 / CD283 contains 22 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain and 1 TIR domain. TLR3 is expressed at high level in placenta and pancreas and also detected in CD11c+ immature dendritic cells. CD283 / TLR3 is only expressed in dendritic cells. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. CD283 / TLR-3 is the key component of innate and adaptive immunity. TLR3 / CD283 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLR3 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Defects in TL-R3 are associated with herpes simplex encephalitis type 2 (HSE2). - Molecular Weight
- 103.7 kDa
- NCBI Accession
- NP_569054
- Pathways
- TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
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