NEFL Protein (AA 2-543) (Fc Tag)
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- Target See all NEFL Proteins
- NEFL (Neurofilament, Light Polypeptide (NEFL))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-543
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NEFL protein is labelled with Fc Tag.
- Purpose
- Recombinant Human NEFL with C-terminal human Fc tag
- Specificity
- NEFL (Ser2-Asp543) hFc (Glu99-Ala330)
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product NEFL Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- NEFL (Neurofilament, Light Polypeptide (NEFL))
- Alternative Name
- NEFL (NEFL Products)
- Synonyms
- NEFL Protein, nefl Protein, zgc:136626 Protein, AI847934 Protein, CMT2E Protein, NF-L Protein, NF68 Protein, Nfl Protein, CMT1F Protein, NFL Protein, XNF-L Protein, neurofilament light Protein, neurofilament, light polypeptide Protein, neurofilament, light polypeptide b Protein, neurofilament, light L homeolog Protein, NEFL Protein, neflb Protein, Nefl Protein, nefl.L Protein
- Background
- Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
- Molecular Weight
- predicted molecular mass of 87.5 kDa after removal of the signal peptide. The apparent molecular mass of NEFL-hFc is 35-55 kDa due to glycosylation.
- UniProt
- P07196
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