NEFL Protein (AA 89-400) (His tag)

Catalog No. ABIN7092803

Product Details

Target: NEFL (Neurofilament, Light Polypeptide (NEFL))

Protein Type: Recombinant

Protein Characteristics: AA 89-400

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This NEFL protein is labelled with His tag.

Purpose: Recombinant human NEFL(89-400) protein with N-terminal 6xHis tag

Specificity: 6xHis tag NEFL (Gln89-Leu400)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: NEFL (Neurofilament, Light Polypeptide (NEFL))

Alternative Name: NEFL (NEFL Products)

Synonyms: NEFL Protein, nefl Protein, zgc:136626 Protein, AI847934 Protein, CMT2E Protein, NF-L Protein, NF68 Protein, Nfl Protein, CMT1F Protein, NFL Protein, XNF-L Protein, neurofilament light Protein, neurofilament, light polypeptide Protein, neurofilament, light polypeptide b Protein, neurofilament, light L homeolog Protein, NEFL Protein, neflb Protein, Nefl Protein, nefl.L Protein

Background: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

Molecular Weight: predicted molecular mass of 36.9 kDa after removal of the signal peptide. The apparent molecular mass of His-NEFL(89-400) is 35-55 kDa due to glycosylation.

UniProt: P07196