GFRAL Protein (AA 19-351) (His tag)
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- Target See all GFRAL Proteins
- GFRAL (GDNF Family Receptor alpha Like (GFRAL))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-351
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GFRAL protein is labelled with His tag.
- Purpose
- Recombinant human GFRAL protein with C-terminal 6xHis tag
- Specificity
- GFRAL (Ser19-Glu351) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product GFRAL Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- GFRAL (GDNF Family Receptor alpha Like (GFRAL))
- Alternative Name
- GFRAL (GFRAL Products)
- Synonyms
- RGD1565220 Protein, C6orf144 Protein, GRAL Protein, UNQ9356 Protein, bA360D14.1 Protein, AY457637 Protein, Gral Protein, GDNF family receptor alpha like Protein, Gfral Protein, GFRAL Protein
- Background
- Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.[UniProtKB/Swiss-Prot Function]
- Molecular Weight
- predicted molecular mass of 38.6 kDa after removal of the signal peptide. The apparent molecular mass of GFRAL-His is 35-55 kDa due to glycosylation.
- UniProt
- Q6UXV0
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