FGFR4 Protein (AA 22-369) (His tag)
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- Target See all FGFR4 Proteins
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 22-369
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FGFR4 protein is labelled with His tag.
- Purpose
- Recombinant Human FGFR4 Protein with C-terminal 6xHis tag
- Specificity
- FGFR4 (Leu22-Asp369) 6xHis Tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product FGFR4 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
- Alternative Name
- FGFR4 (FGFR4 Products)
- Synonyms
- FGFR4 Protein, XFGFR-4 Protein, XFGFR-4a Protein, cd334 Protein, fgfr-4 Protein, jtk2 Protein, tkf Protein, xfgfr4 Protein, CD334 Protein, JTK2 Protein, TKF Protein, Fgfr-4 Protein, etID309818.21 Protein, wu:fc13h10 Protein, zgc:111935 Protein, fgfr-4c Protein, fgfr4 Protein, fibroblast growth factor receptor 4 Protein, fibroblast growth factor receptor 4 S homeolog Protein, FGFR4 Protein, fgfr4 Protein, Fgfr4 Protein, fgfr4.S Protein
- Background
- The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]
- Molecular Weight
- predicted molecular mass of 39.3 kDa after removal of the signal peptide.The apparent molecular mass of FGFR4-His is 35-70 kDa due to glycosylation.
- UniProt
- P22455
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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