IL-18 Protein (AA 37-197) (mFc Tag)
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- Target See all IL-18 (IL18) Proteins
- IL-18 (IL18) (Interleukin 18 (IL18))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 37-197
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL-18 protein is labelled with mFc Tag.
- Purpose
- Recombinant Human IL18 with C-terminal mouse Fc tag
- Specificity
- IL18 (Thr37-Asp197) mFc (Pro99-Lys330)
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product IL18 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- IL-18 (IL18) (Interleukin 18 (IL18))
- Alternative Name
- IL18 (IL18 Products)
- Synonyms
- Igif Protein, Il-18 Protein, IL-18 Protein, IGIF Protein, ChIL-18 Protein, IL-1g Protein, IL1F4 Protein, IL18 Protein, interleukin 18 Protein, Il18 Protein, IL18 Protein
- Background
- The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
- Molecular Weight
- predicted molecular mass of 44.3 kDa after removal of the signal peptide.The apparent molecular mass of IL18-mFc is 35-55 kDa due to glycosylation.
- UniProt
- Q14116
- Pathways
- Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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