IL-21 Protein (AA 30-162) (mFc Tag)
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- Target See all IL-21 (IL21) Proteins
- IL-21 (IL21) (Interleukin 21 (IL21))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 30-162
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL-21 protein is labelled with mFc Tag.
- Purpose
- Recombinant Human IL21 with C-terminal mouse Fc tag
- Specificity
- IL21 (Gln30-Ser162) mFc (Pro99-Lys330)
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product IL21 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- IL-21 (IL21) (Interleukin 21 (IL21))
- Alternative Name
- IL21 (IL21 Products)
- Synonyms
- IL-21 Protein, Za11 Protein, interleukin 21 Protein, IL21 Protein, Il21 Protein
- Background
- This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
- Molecular Weight
- predicted molecular mass of 41.6 kDa after removal of the signal peptide.The apparent molecular mass of IL21-mFc is 35-55 kDa due to glycosylation.
- UniProt
- Q9HBE4
- Pathways
- JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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