IL-21 Protein (AA 30-162) (mFc Tag)

Catalog No. ABIN7092720

Product Details

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Protein Type: Recombinant

Protein Characteristics: AA 30-162

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This IL-21 protein is labelled with mFc Tag.

Purpose: Recombinant Human IL21 with C-terminal mouse Fc tag

Specificity: IL21 (Gln30-Ser162) mFc (Pro99-Lys330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Alternative Name: IL21 (IL21 Products)

Synonyms: IL-21 Protein, Za11 Protein, interleukin 21 Protein, IL21 Protein, Il21 Protein

Background: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Molecular Weight: predicted molecular mass of 41.6 kDa after removal of the signal peptide.The apparent molecular mass of IL21-mFc is 35-55 kDa due to glycosylation.

UniProt: Q9HBE4

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response