KREMEN1 Protein (AA 21-392) (Fc Tag)

Catalog No. ABIN7013613

Product Details

Target: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 21-392

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This KREMEN1 protein is labelled with Fc Tag.

Characteristics: Human Kremen-1 protein, Fc Tag

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Target Details

Target: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Alternative Name: KREMEN1 (KREMEN1 Products)

Synonyms: KREMEN1 Protein, krm1 Protein, kremen Protein, kremem1 Protein, KREMEN Protein, KRM1 Protein, AV002070 Protein, Kremen Protein, Krm1 Protein, si:ct737139.1 Protein, si:dkeyp-7c9.1 Protein, kringle containing transmembrane protein 1 Protein, kringle containing transmembrane protein 1 S homeolog Protein, KREMEN1 Protein, kremen1 Protein, Kremen1 Protein, kremen1.S Protein

Background: Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6). Kremen1 is considered as one component of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates. Additionally, KREMEN1 (KRM1) has also been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD).

Molecular Weight: 67.4 kDa

Pathways: WNT Signaling