Topoisomerase II alpha Protein (AA 1354-1473)

Catalog No. ABIN7013599

Product Details

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Protein Type: Recombinant

Protein Characteristics: AA 1354-1473

Origin: Human

Source: Escherichia coli (E. coli)

Sequence: AA 1354-1473

Characteristics: Cynomolgus TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag (MALS verified)

Purity: >90 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 mM Tris, 0.5 M KCl, pH 8.0

Storage: -80 °C

Target Details

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Alternative Name: TOP2A (TOP2A Products)

Synonyms: TOP2 Protein, TP2A Protein, TOP2A Protein, Top-2 Protein, TOP-2 Protein, F12B17.110 Protein, F12B17_110 Protein, thimet metalloendopeptidase 2 Protein, fc08c07 Protein, wu:fc08c07 Protein, DNA topoisomerase II alpha Protein, DNA topoisomerase II, alpha isozyme Protein, topoisomerase (DNA) II alpha Protein, Zincin-like metalloproteases family protein Protein, TOP2A Protein, Bm1_08705 Protein, Top2a Protein, AT5G10540 Protein, top2a Protein

Background: DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.

Molecular Weight: 12.8 kDa

NCBI Accession: NP_001058

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases