CD39 Protein (AA 38-478) (mFc Tag)
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- Target See all CD39 (ENTPD1) Proteins
- CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 38-478
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CD39 protein is labelled with mFc Tag.
- Characteristics
- Human CD39 Protein, Mouse IgG2a Fc Tag
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 0.1 EU per μg by the LAL method.
- Top Product
- Discover our top product ENTPD1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 20 mM Tris, 500 mM Argnine, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
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- Target
- CD39 (ENTPD1) (Ectonucleoside Triphosphate diphosphohydrolase 1 (ENTPD1))
- Alternative Name
- CD39 (ENTPD1 Products)
- Synonyms
- ATPDase Protein, CD39 Protein, NTPDase-1 Protein, MGC80631 Protein, zgc:100819 Protein, entpd1 Protein, MGC79567 Protein, 2610206B08Rik Protein, AA408691 Protein, Cd39 Protein, ectonucleoside triphosphate diphosphohydrolase 1 Protein, ectonucleoside triphosphate diphosphohydrolase 1 L homeolog Protein, ENTPD1 Protein, Entpd1 Protein, entpd1.L Protein, entpd1 Protein
- Background
- CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.
- Molecular Weight
- 77.3 kDa
- NCBI Accession
- NP_001767
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