CD8 alpha Protein (AA 22-182) (His tag)

Catalog No. ABIN7013444

This Recombinant CD8 alpha protein is produced in HEK-293 Cells.

Quick Overview for CD8 alpha Protein (AA 22-182) (His tag) (ABIN7013444)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 22-182

Purification tag / Conjugate: This CD8 alpha protein is labelled with His tag.

Characteristics: Human CD8 alpha / CD8A Protein, His Tag

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Target Details

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8 alpha

Background: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Molecular Weight: 19.5 kDa

NCBI Accession: NP_001759

Pathways: TCR Signaling