TNFSF14 Protein (AA 74-240) (Fc Tag)
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- Target See all TNFSF14 Proteins
- TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 74-240
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TNFSF14 protein is labelled with Fc Tag.
- Characteristics
- Human LIGHT / TNFSF14 Protein, Fc Tag (active trimer) (MALS verified)
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product TNFSF14 Protein
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- Application Notes
- MALS verified
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
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- Target
- TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))
- Alternative Name
- LIGHT (TNFSF14 Products)
- Synonyms
- TNFSF14 Protein, CD258 Protein, HVEML Protein, LIGHT Protein, LTg Protein, TR2 Protein, HVEM-L Protein, Ly113 Protein, TNF superfamily member 14 Protein, tumor necrosis factor (ligand) superfamily, member 14 Protein, TNFSF14 Protein, Tnfsf14 Protein
- Background
- Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
- Molecular Weight
- 82.6 kDa
- Pathways
- Cancer Immune Checkpoints
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