ENPP3 Protein (AA 46-874) (His tag)
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- Target See all ENPP3 Proteins
- ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 46-874
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ENPP3 protein is labelled with His tag.
- Purpose
- Mouse ENPP3 / CD203c Protein, His Tag (active enzyme, MALS verified)
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ENPP3 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
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- Target
- ENPP3 (Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3))
- Alternative Name
- ENPP3 (ENPP3 Products)
- Synonyms
- B10 Protein, CD203c Protein, NPP3 Protein, PD-IBETA Protein, PDNP3 Protein, Npp3 Protein, RB13-6 Protein, AI876438 Protein, ENPP3 Protein, ectonucleotide pyrophosphatase/phosphodiesterase 3 Protein, ectonucleotide pyrophosphatase/phosphodiesterase 3 L homeolog Protein, ENPP3 Protein, Enpp3 Protein, enpp3 Protein, enpp3.L Protein
- Background
- The human NPP family contains seven members which can be classified into two groups according to their substrate preferences. The first class comprises the nucleotide-degrading proteins NPP1, 3 and 4. NPP3 (CD203c, ENPP3) is expressed in multiple organs, including on epithelial and mucosal surfaces, and notably on basophils and mast cells. Activation of basophils by antigen-bound IgE leads to release of inflammatory mediators and rapid upregulation of NPP3 to the cell surface. This protein is in fact a common marker for diagnosing allergen sensitivity with patient basophils by flow cytometry. Basophils and mast cells mediate the response to certain pathogens, as well as acute and chronic allergic reactions. Following activation, these cells release ATP, which further stimulates them in an autocrine manner. NPP3 upregulation serves to degrade ATP and suppress chronic allergic inflammation (but not the acute response).
- Molecular Weight
- 95.8 kDa
- NCBI Accession
- NP_598766
- Pathways
- Regulation of Muscle Cell Differentiation, Negative Regulation of Transporter Activity
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