IL12A & IL27B (AA 20-189) (Active) protein (His tag)
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- Target
- IL12A & IL27B
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 20-189
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Origin
- Human, Rat
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- His tag
- Purpose
- Human IL-23 alpha & Rat IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- IL12A & IL27B
- Alternative Name
- IL23A & IL12B
- Background
- Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
- Molecular Weight
- 20.6 kDa, 35.9 kDa
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