ROR1 Protein (AA 30-403) (Fc Tag,FITC)
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- Target See all ROR1 Proteins
- ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 30-403
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ROR1 protein is labelled with Fc Tag,FITC.
- Characteristics
- FITC-Labeled Human ROR1 Protein, Fc Tag
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ROR1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))
- Alternative Name
- ROR1 (ROR1 Products)
- Synonyms
- NTRKR1 Protein, dJ537F10.1 Protein, 2810404D04Rik Protein, Ntrkr1 Protein, mRor1 Protein, RGD1559469 Protein, ROR1 Protein, fi34e02 Protein, si:dkey-209n16.1 Protein, wu:fi34e02 Protein, receptor tyrosine kinase like orphan receptor 1 Protein, receptor tyrosine kinase-like orphan receptor 1 Protein, ROR1 Protein, Ror1 Protein, ror1 Protein
- Background
- Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
- Molecular Weight
- 68.6 kDa
- Pathways
- RTK Signaling, WNT Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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