GDF2 Protein (AA 320-429)

Catalog No. ABIN6973076

Product Details

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 320-429

Origin: Human

Source: HEK-293 Cells

Characteristics: Human GDF-2 Protein, Tag Free

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: ACN, TFA in Water

Storage: -20 °C

Target Details

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Alternative Name: GDF-2 (GDF2 Products)

Synonyms: bmp9 Protein, BMP-9 Protein, BMP9 Protein, Bmp9 Protein, DSL1 Protein, growth differentiation factor 2 Protein, gdf2 Protein, GDF2 Protein, Gdf2 Protein

Background: Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.

Molecular Weight: 12.1 kDa

Pathways: Transition Metal Ion Homeostasis