IL1A Protein (AA 113-271) (Fc Tag)
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- Target See all IL1A Proteins
- IL1A (Interleukin 1 alpha (IL1A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 113-271
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL1A protein is labelled with Fc Tag.
- Purpose
- Recombinant Human IL1A Protein with C-terminal human Fc tag
- Specificity
- IL1A (Ser113-Ala271) hFc (Glu99-Ala330)
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product IL1A Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- IL1A (Interleukin 1 alpha (IL1A))
- Alternative Name
- IL1A (IL1A Products)
- Synonyms
- IL-1A Protein, IL1 Protein, IL1-ALPHA Protein, IL1F1 Protein, IL-6 Protein, Il-1a Protein, IL-1 alpha Protein, IL-1alpha Protein, L1A Protein, interleukin 1 alpha Protein, interleukin 6 Protein, IL1A Protein, IL6 Protein, Il1a Protein
- Background
- The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
- Molecular Weight
- predicted molecular mass of 44.2 kDa after removal of the signal peptide.The apparent molecular mass of IL1A-hFc is 35-55 kDa due to glycosylation.
- UniProt
- P01583
- Pathways
- NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
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