IFNAR2 Protein (AA 27-243) (Fc Tag)
-
- Target See all IFNAR2 Proteins
- IFNAR2 (Interferon alpha/beta Receptor 2 (IFNAR2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 27-243
-
Origin
- Human
-
Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IFNAR2 protein is labelled with Fc Tag.
- Purpose
- Recombinant human IFNAR2 protein with C-terminal human Fc tag
- Specificity
- IFNAR2 (Ile27-Lys243) hFc (Glu99-Ala330)
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
-
- Target
- IFNAR2 (Interferon alpha/beta Receptor 2 (IFNAR2))
- Alternative Name
- IFNAR2 (IFNAR2 Products)
- Synonyms
- AI747302 Protein, Ifnar-2 Protein, IFN-R Protein, IFN-alpha-REC Protein, IFNABR Protein, IFNARB Protein, IFN-R-2 Protein, IFNBR Protein, interferon alpha and beta receptor subunit 2 Protein, interferon (alpha and beta) receptor 2 Protein, IFNAR2 Protein, Ifnar2 Protein
- Background
- The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]
- Molecular Weight
- predicted molecular mass of 50.9 kDa after removal of the signal peptide. The apparent molecular mass of IFNAR2-hFc is 55-70 kDa due to glycosylation.
- UniProt
- P48551
- Pathways
- JAK-STAT Signaling, Hepatitis C
-