CCR9 Protein (AA 1-48) (Fc Tag)

Catalog No. ABIN6964146

Product Details

Target: CCR9 (Chemokine (C-C Motif) Receptor 9 (CCR9))

Protein Type: Recombinant

Protein Characteristics: AA 1-48

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CCR9 protein is labelled with Fc Tag.

Purpose: Recombinant Human CCR9 with C-terminal human Fc tag

Specificity: CCR9 (Met1-Ser48) hFc (Glu99-Ala330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: CCR9 (Chemokine (C-C Motif) Receptor 9 (CCR9))

Alternative Name: CCR9 (CCR9 Products)

Synonyms: CC-CKR-9 Protein, CDw199 Protein, GPR-9-6 Protein, GPR28 Protein, A130091K22Rik Protein, Cmkbr10 Protein, C-C motif chemokine receptor 9 Protein, chemokine (C-C motif) receptor 9 Protein, CCR9 Protein, Ccr9 Protein

Background: The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

Molecular Weight: predicted molecular mass of 31.6 kDa after removal of the signal peptide. The apparent molecular mass of CCR9-hFc is 35-55 kDa due to glycosylation.

UniProt: P51686