CD8 alpha Protein (Fc Tag)

Catalog No. ABIN6964139

Product Details

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CD8 alpha protein is labelled with Fc Tag.

Sequence: CD8A(Ser22-Asp182)+hFc(Glu99-Ala330)

Characteristics: Tagged Protein: C-Human Fc tag

Purification: affinity purification

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Preservative: Without preservative

Storage: -80 °C

Storage Comment: Store at -80°C for 12 months (Avoid repeated freezing and thawing)

Expiry Date: 12 months

Target Details

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8A (CD8A Products)

Background: Synonymes: CD8, Leu2, p32
Description: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein.

Molecular Weight: 43.23 kDa

UniProt: P01732

Pathways: TCR Signaling