CD22 Protein (AA 20-687) (Fc-His Tag)
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- Target See all CD22 Proteins
- CD22 (CD22 Molecule (CD22))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-687
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This CD22 protein is labelled with Fc-His Tag.
- Application
- ELISA
- Purpose
- Recombinant human CD22 protein with C-terminal human Fc and 6xHis tag
- Specificity
- CD22 (Asp20-Arg687) hFc (Glu99-Ala330) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product CD22 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- CD22 (CD22 Molecule (CD22))
- Alternative Name
- CD22 (CD22 Products)
- Synonyms
- A530093D23 Protein, Lyb-8 Protein, Lyb8 Protein, SIGLEC-2 Protein, SIGLEC2 Protein, siglec-2 Protein, CD22 antigen Protein, CD22 molecule Protein, Cd22 Protein, CD22 Protein
- Background
- B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
- Molecular Weight
- predicted molecular mass of 102.1 kDa after removal of the signal peptide. The apparent molecular mass of CD22-hFc-His is 130-180 kDa due to glycosylation.
- Gene ID
- 933
- UniProt
- P20273
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