BEBOV GP Protein (AA 33-324) (His tag)
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- Target See all BEBOV GP products
- BEBOV GP (Bundibugyo Ebola Virus Envelope Glycoprotein (BEBOV GP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 33-324
- Origin
- Ebola Virus
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This BEBOV GP protein is labelled with His tag.
- Purpose
- Recombinant Ebolavirus BDBV(subtype Bundibugyo,strain Uganda 2007) Small/secreted Glycoprotein (sGP) protein produced in HEK293 cells. Protein contains a C-terminal 6x His-tag
- Specificity
- Recombinant Ebolavirus BDBV (subtype Bundibugyo,strain Uganda 2007) Small/secreted Glycoprotein (sGP) produced in HEK293 cells, incorporating a C-terminal 6x His-tag. Greater than 80% purity.
- Characteristics
- Ebola Virus Secreted Glycoprotein (sGP) (Bundibugyo)
- Purity
- >95 %
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- Comment
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Ebola virus secreted glycoprotein protein (sGP) is Ile 33 – Arg 324 (Accession # B8XCN1), fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 34.3 kDa. The protein is expressed in HEK293 cells. DTT-reduced Protein migrates as 40-55 kDa in SDS-PAGE.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS pH 7.4
- Storage
- 4 °C
- Storage Comment
- 4°C
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- Target
- BEBOV GP (Bundibugyo Ebola Virus Envelope Glycoprotein (BEBOV GP))
- Alternative Name
- Ebola Secreted Glycoprotein (sGP) (Bundibugyo) (BEBOV GP Products)
- Target Type
- Viral Protein
- Background
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The virulence of EBOV may be partially attributed to the Ebola virus secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. Ebola virus secreted glycoprotein is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. Mature sGP is produced from a precursor by proteolytic cleavage by host cell proteases such as furin. sGP monomers bind to each other to form a homodimer.
The role of Ebola virus secreted glycoprotein in EBOV pathogenesis is unclear, but is examined in detail by de la Vega et al (2015) - UniProt
- B8XCN1
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