Neuregulin 1 Protein (NRG1)
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- Target See all Neuregulin 1 (NRG1) Proteins
- Neuregulin 1 (NRG1)
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Supplier Product No.
- 009-001-w05-0010
- Supplier
- Rockland
- Purpose
- Human Neuregulin 1-beta Recombinant Protein
- Purification
- Neuregulin 1-beta purity was determined to be greater than 95% as determined by reducing and non-reducing SDS-pAGE.
- Purity
- 95,00%
- Endotoxin Level
- Measured by LAL is typically ≤ 1 EU/μg protein.
- Biological Activity Comment
- The activity is determined by the ability to stimulate proliferation of MC-7 cells under serum free conditions and is typically less than 0.3 ng/mL.
- Top Product
- Discover our top product NRG1 Protein
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Neuregulin 1 (NRG1) (AA 20-242) protein (Fc Tag)
NRG1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Neuregulin 1 (NRG1) (AA 119-237) protein (His-IF2DI Tag)NRG1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Neuregulin 1 (NRG1) (AA 1-241) protein (GST tag)NRG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Application Notes
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Other: User Optimized
Application_Note: Neuregulin 1-beta Recombinant Protein has been tested by SDS-PAGE and is suitable as a control for polyclonal or monoclonal anti-Neuregulin 1-beta in immunological assays.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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Reconstitution_Buffer: Restore with deionized water (or equivalent)
Reconstitution_Volume: 10 μL (10-100 μL)
- Concentration
- 0.1 mg/mL
- Buffer
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Buffer: 0.1 % Trifluoroacetic acid
Stabilizer: None
- Preservative
- Without preservative
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store vial at 4° C prior to restoration. Dilute only prior to immediate use. Maintain sterility. This product DOES NOT contain preservative. DO NOT VORTEX. We recommend adding a carrier protein such as HSA or BSA to 0.1% (i.e. 1.0 mg/mL). For best results aliquot contents and freeze at -20° C or colder. Avoid cycles of freezing and thawing. Centrifuge vial before each opening to dislodge contents from the cap and to clarify if contents are not clear after standing at room temperature.
- Expiry Date
- 6 months
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- Target
- Neuregulin 1 (NRG1)
- Alternative Name
- NRG1 (NRG1 Products)
- Background
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Synonyms: Acetylcholine receptor-inducing activity (ARIA), Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, Neu differentiation factor, NGR beta 1, heregulin, HRG1 beta, Sensory and motor neuron-derived factor
Background: Neuregulin 1-beta (NRG1) is one of many isoforms of NRG that contains a soluble EGF-like domain. Alpha and beta varients are distinguished by difference in length at the C terminus. The EGF-like domain signals through receptors ErbB2, ErbB3, and ErbB4 to act as a growth factor. NRG isoforms are particularly important for nervous system and cardiovasucular development. Recombinant human NRG1-beta is a non-glycosylated protein, containing 66 amino acids, with a molecular weight of 7.6 kDa.
- UniProt
- Q02297
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
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