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IL-21 Protein

Rockland 009-001-v61-0100 IL21 Origin: Human Host: Escherichia coli (E. coli) Recombinant 95,00% SDS
Rockland
Catalog No. ABIN6700077
Supplier Product No.: 009-001-v61-0100
  • Target See all IL-21 (IL21) Proteins
    IL-21 (IL21) (Interleukin 21 (IL21))
    Protein Type
    Recombinant
    Origin
    • 30
    • 12
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 27
    • 15
    • 4
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    SDS-PAGE (SDS)
    Supplier Product No.
    009-001-v61-0100
    Supplier
    Rockland
    Purpose
    Human Interleukin-21 Recombinant Protein
    Purification
    Interleukin-21 purity was determined to be greater than 95% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE.
    Purity
    95,00%
    Endotoxin Level
    Measured by LAL is typically ≤ 1 EU/μg protein.
    Biological Activity Comment
    The activity is determined by the dose-dependent stimulation of B9 cells and is typically less than 50 ng/mL.
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  • Application Notes

    Other: User Optimized

    Application_Note: Interleukin-21 Recombinant Protein has been tested by SDS-PAGE and biological activity and is suitable as a control for polyclonal or monoclonal anti-Interleukin-21 in immunological assays.

    Comment

    Suggested_Applications: Cellular Assay

    Other_Performance_Data:

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution

    Reconstitution_Buffer: Restore with deionized water (or equivalent)

    Reconstitution_Volume: 100 μL

    Buffer

    Buffer: 0.01 M Sodium Phosphate, pH 7.5

    Stabilizer: None

    Preservative
    Without preservative
    Storage
    4 °C,-20 °C
    Storage Comment
    Store vial at 4° C prior to restoration. Dilute only prior to immediate use. Maintain sterility. This product DOES NOT contain preservative. DO NOT VORTEX. We recommend adding a carrier protein such as HSA or BSA to 0.1% (i.e. 1.0 mg/mL). For best results aliquot contents and freeze at -20° C or colder. Avoid cycles of freezing and thawing. Centrifuge vial before each opening to dislodge contents from the cap and to clarify if contents are not clear after standing at room temperature.
    Expiry Date
    6 months
  • Target
    IL-21 (IL21) (Interleukin 21 (IL21))
    Alternative Name
    IL21 (IL21 Products)
    Background

    Synonyms: Za11

    Background: Interleukin-21 (IL-21) is a member of the common gamma-chain family of cytokines (includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15) and is expressed by activated CD4+ T cells. IL-21 has a private receptor known as IL-21R, which is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells. Recombinant human IL-21 is a non-glycosylated protein, containing 133 amino acids, with a total molecular weight of 15.5 kDa.

    UniProt
    Q9HBE4
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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