AKR1D1 Protein (AA 1-326) (His tag)
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- Target See all AKR1D1 Proteins
- AKR1D1 (Aldo-Keto Reductase Family 1, Member D1 (AKR1D1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-326
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This AKR1D1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- AKR1D1, 1-326aa, Human, His tag, E.coli
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product AKR1D1 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 100mM NaCl
- Storage
- 4 °C
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- Target
- AKR1D1 (Aldo-Keto Reductase Family 1, Member D1 (AKR1D1))
- Alternative Name
- AKR1D1 (AKR1D1 Products)
- Synonyms
- 3o5bred Protein, CBAS2 Protein, SRD5B1 Protein, 3-oxo-5-beta-steroid 4-dehydrogenase-like Protein, aldo-keto reductase family 1 member D1 Protein, aldo-keto reductase family 1, member D1 Protein, aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) Protein, LOC491379 Protein, AKR1D1 Protein, Akr1d1 Protein
- Background
- Aldo-keto reductase family 1, member D1, also known as AKR1D1, is a member of the AKR superfamily. The AKR family of proteins are soluble NADPH oxidoreductases. They play important roles in the metabolism of drugs, carcinogens and reactive aldehydes. AKR1D1 is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones which carry a delta (4)-3-one structure. AKR1D1 is highly expressed in liver, colon and testis. Deficiency of this enzyme may contribute to hepatic dysfunction. Recombinant human AKR1D1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Aldo-keto reductase family 1, member D1, 3o5bred, CBAS2, SRD5B1. NCBI no.: NP_005980
- Molecular Weight
- 39.5 kDa (346aa) confirmed by MALDI-TOF
- Pathways
- Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process
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