ARHGDIA Protein (AA 24-204) (His tag)

Catalog No. ABIN667259

Product Details

Target: ARHGDIA (rho GDP Dissociation Inhibitor (GDI) alpha (ARHGDIA))

Protein Type: Recombinant

Protein Characteristics: AA 24-204

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ARHGDIA protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: ARHGDIA, 24-204aa, Human, His tag, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Storage: 4 °C

Target Details

Target: ARHGDIA (rho GDP Dissociation Inhibitor (GDI) alpha (ARHGDIA))

Alternative Name: ARHGDIA (ARHGDIA Products)

Synonyms: GDIA1 Protein, NPHS8 Protein, RHOGDI Protein, RHOGDI-1 Protein, Bles01 Protein, zgc:55554 Protein, zgc:77681 Protein, wu:fa96g11 Protein, ARHGDIA Protein, NV15502 Protein, 5330430M07Rik Protein, Gdi-1 Protein, Rho-GDI Protein, RhoDGI Protein, RhoGDI-1 Protein, arhgdia Protein, MGC84535 Protein, gdia1 Protein, rhogdi Protein, rhogdi-1 Protein, rhogdi1 Protein, Rho GDP dissociation inhibitor alpha Protein, Rho GDP dissociation inhibitor (GDI) alpha Protein, rho GDP-dissociation inhibitor 2 Protein, Rho GDP dissociation inhibitor (GDI) alpha L homeolog Protein, ARHGDIA Protein, Arhgdia Protein, arhgdia Protein, LOC100120432 Protein, arhgdia.L Protein

Background: Rho GDP-dissociation inhibitor 1, also known ARHGDIA, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. Localized to the cytoplasm, ARHGDIA inhibits the dissociation of GDP from Rho proteins, thereby preventing GTP from binding to and subsequently activating Rho proteins. In humans ARHGDIA can be phosphorylated at Ser 101 by p21-activated kinase, an event that inhibits ARHGDIA activity and may result in positive feedback regulation of certain ARHGDIA target proteins. Recombinant human ARHGDIA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Rho GDP-dissociation inhibitor 1, GDIA1, RHOGDI, RHOGDI-1, Rho-GDI alpha. NCBI no.: NP_004300

Molecular Weight: 22.9 kDa (202aa) confirmed by MALDI-TOF

Pathways: Neurotrophin Signaling Pathway