LIF Protein (AA 23-202) (HIS-GST)

Catalog No. ABIN667245

Product Details

Target: LIF (Leukemia Inhibitory Factor (LIF))

Protein Type: Recombinant

Protein Characteristics: AA 23-202

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This LIF protein is labelled with HIS-GST.

Application: SDS-PAGE (SDS)

Characteristics: LIF, 23-202aa, Human, His-GST tag, E.coli

Purity: > 90 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 50mM NaCl

Storage: 4 °C

Target Details

Target: LIF (Leukemia Inhibitory Factor (LIF))

Alternative Name: LIF (LIF Products)

Synonyms: CDF Protein, DIA Protein, HILDA Protein, MLPLI Protein, LIF, interleukin 6 family cytokine Protein, leukemia inhibitory factor Protein, LIF Protein, Lif Protein

Background: Leukemia inhibitory factor, also known as LIF, is a pleiotropic cytokine that is expressed by a wide variety of cells including activated T lymphocytes, monocytes, mast cells and neuronal cells. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Recombinant human LIF protein, fused to His GST-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Leukemia inhibitory factor, CDF, HILDA, DIA, D FACTOR, MLPLI, Emfilermin. NCBI no.: NP_002300

Molecular Weight: 47.2 kDa (415aa) confirmed by MALDI-TOF

Pathways: JAK-STAT Signaling, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding