COMT Protein (AA 51-271)

Catalog No. ABIN666744

Product Details

Target: COMT (Catechol-O-Methyltransferase (COMT))

Protein Type: Recombinant

Protein Characteristics: AA 51-271

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Characteristics: COMT, 51-271 aa, Human, Recombinant, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM MgCl2, 10% glycerol

Storage: 4 °C

Target Details

Target: COMT (Catechol-O-Methyltransferase (COMT))

Alternative Name: COMT (COMT Products)

Background: Catechol-O-methyltrasferase (COMT) is an enzyme that catalyses the transfer of the methyl group of S-adenosylmethionine (SAM) into catechol substrates such as levodopa, dopamine, epinephrine, and norepinephirine in the presence of Mg2+. COMT appears to be located in the postsynaptic neuron and plays roles in the metabolism of catechol estrogens and the inactivation of catecholamine neurotransmitters though enzymatic degradation. COMT inhibitors prevent levodopa degradation, increase its availability and are used in the treatment of patients with Parkinson's disease. Recombinant human COMT protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Catechol-O-methyltransferase , Catechol-O-methyltransferase , COMT. NCBI no.: NP_000745

Molecular Weight: 24.4 kDa (221 aa), confirmed by MALDI-TOF.

Pathways: Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome