FH Protein (AA 44-510)

Catalog No. ABIN666730

Product Details

Target: FH (Fumarate Hydratase (FH))

Protein Type: Recombinant

Protein Characteristics: AA 44-510

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Characteristics: Fumarase, 44-510aa, Human, Recombinant, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH 8.0)

Storage: 4 °C

Target Details

Target: FH (Fumarate Hydratase (FH))

Alternative Name: Fumarase (FH Products)

Synonyms: FH Protein, DDBDRAFT_0205237 Protein, DDBDRAFT_0231397 Protein, DDBDRAFT_0231400 Protein, DDB_0205237 Protein, DDB_0231397 Protein, DDB_0231400 Protein, HLRCC Protein, LRCC Protein, MCL Protein, MCUL1 Protein, Fh1 Protein, im:7152785 Protein, ns:zf-e152 Protein, zf-e152 Protein, zgc:66253 Protein, zgc:77498 Protein, Fh Protein, Fh-1 Protein, fumarate hydratase Protein, fumarate hydratase 1 Protein, FH Protein, fumH Protein, Fh Protein, fh Protein, Fh1 Protein

Background: Fumarase (Fumarate hytdratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid (TCA), or Krebs cycle. This enzyme exists in both a cytosolic form and an N-terminal extended mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase deficiency can lead to progressive encephalopathy, cerebral atrophy and developmental delay and this enzyme also is thought to act as a tumor suppressor. Recombinant Fumarase was expressed in E.coli and was purified by conventional chromatography techniques. Synonyms: FH, HLRCC, LRCC, MCL, MCUL1 , Fumarate hydratase Fumarase, Fumarate hydratase mitochondrial, MCUL 1, Multiple hereditary cutaneous leiomyomata. NCBI no.: NP_000134

Molecular Weight: 50.2kDa (467aa), confirmed by MALDI-TOF.