FRZB Protein (AA 33-325) (His tag)
-
- Target See all FRZB Proteins
- FRZB (Frizzled-Related Protein (FRZB))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 33-325
-
Origin
- Human
-
Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This FRZB protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- ADPAACEPVR IPLCKSLPWN MTKMPNHLHH STQANAILAI EQFEGLLGTH CSPDLLFFLC AMYAPICTID FQHEPIKPCK SVCERARQGC EPILIKYRHS WPENLACEEL PVYDRGVCIS PEAIVTADGA DFPMDSSNGN CRGASSERCK CKPIRATQKT YFRNNYNYVI RAKVKEIKTK CHDVTAVVEV KEILKSSLVN IPRDTVNLYT SSGCLCPPLN VNEEYIIMGY EDEERSRLLL VEGSIAEKWK DRLGKKVKRW DMKLRHLGLS KSDSSNSDST QSQKSGRNSN PRQARNHHHH HH
- Purity
- > 90 % by SDS - PAGE
- Endotoxin Level
- < 1.0 EU per 1ug of protein (determined by LAL method)
- Top Product
- Discover our top product FRZB Protein
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In Phosphate Buffered Saline ( pH 7.4) containing 10 % glycerol.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
-
- Target
- FRZB (Frizzled-Related Protein (FRZB))
- Alternative Name
- FRZB (FRZB Products)
- Synonyms
- Frp Protein, Sfrp3 Protein, frezzled Protein, fritz Protein, frzb-1 Protein, FRE Protein, FRITZ Protein, FRP-3 Protein, FRZB-1 Protein, FRZB-PEN Protein, FRZB1 Protein, FZRB Protein, OS1 Protein, SFRP3 Protein, SRFP3 Protein, hFIZ Protein, Frzb-1 Protein, frizzled-related protein Protein, Frzb Protein, FRZB Protein
- Background
- FRZB, also known as secreted frizzled-related protein 3, is a member of the family of Wnt-binding proteins with homology to the ligand binding domain of the Frizzled receptors. It is widely expressed in adult mammalian tissues and in chondrocytes. It is a key factors in blocking hypertrophic differentiation of human MSCs (hMSCs) and important in skeletal development in the embryo and fetus. It acts as an agonist of Wnt signaling and promotes invasive behavior. It has a role in regulating cell growth and differentiation in specific cell types. It also functions as a tumor suppressor in a variety of cancers. Recombinant human FRZB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
- Molecular Weight
- 34.2kDa (302aa) 28-40kDa (SDS-PAGE under reducing conditions)
- NCBI Accession
- NP_001454
- UniProt
- Q92765
- Pathways
- WNT Signaling, Positive Regulation of fat Cell Differentiation
-