EDAR Protein (AA 27-187) (hIgG-His-tag)
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- Target See all EDAR Proteins
- EDAR (Ectodysplasin A Receptor (EDAR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 27-187
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Origin
- Mouse
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This EDAR protein is labelled with hIgG-His-tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMTTYNNK GPKPERGRFL HFHSVTFWVG NAKQAASFYC NKMGFEPLAY RGLETGSREV VSHVIKQGKI VFVLCSALNP WNKEMGDHLV KHGDGVKDIA FEVEDCDHIV QKARERGAKI VREPWVEQDK FGKVKFAVLQ TYGDTTHTLV EKINYTGRFL PGFEAPTYKD TLLPKLPRCN LEIIDHIVGN QPDQEMQSAS EWYLKNLQFH RFWSVDDTQV HTEYSSLRSI VVTNYEESIK MPINEPAPGR KKSQIQEYVD YNGGAGVQHI ALKTEDIITA IRHLRERGTE FLAAPSSYYK LLRENLKSAK IQVKESMDVL EELHILVDYD EKGYLLQIFT KPMQDRPTLF LEVIQRHNHQ GFGAGNFNSL FKAFEEEQAL RGNLTDLEPN GVRSGM
- Purity
- > 90 % by SDS-PAGE
- Top Product
- Discover our top product EDAR Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- EDAR (Ectodysplasin A Receptor (EDAR))
- Alternative Name
- EDAR (EDAR Products)
- Synonyms
- rs3 Protein, edar Protein, EDAR Protein, MGC88893 Protein, DL Protein, ECTD10A Protein, ECTD10B Protein, ED1R Protein, ED3 Protein, ED5 Protein, EDA-A1R Protein, EDA1R Protein, EDA3 Protein, HRM1 Protein, dl Protein, RGD1561714 Protein, ectodysplasin A receptor Protein, ectodysplasin-A receptor Protein, edar Protein, EDAR Protein, Edar Protein
- Background
- Hpd, also known as 4-hydroxyphenylpyruvate dioxygenase, is a Fe-containing enzyme that catalyzes the second reaction in the catabolism of tyrosine the conversion of 4-hydroxyphenylpyruvate to homogentisate. Existing as a homodimer, Hpd uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. Defects in the gene encoding Hpd are the cause of tyrosinemia type 3 and hawkinsinuria, both of which are inborn errors of metabolism that are associated with a variety of symptoms, including mental retardation and seizures and hair and urine abnormalities. Recombinant mouse Hpd protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 47.4 kDa (416aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_032303
- UniProt
- P49429
- Pathways
- Tube Formation, Ubiquitin Proteasome Pathway
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