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CST6 Protein (AA 29-149) (His tag)

CST6 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS Active
Catalog No. ABIN6387720
  • Target See all CST6 Proteins
    CST6 (Cystatin E/M (CST6))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 29-149
    Origin
    • 7
    • 1
    Human
    Source
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This CST6 protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    MGSSHHHHHH SSGLVPRGSH MRPQERMVGE LRDLSPDDPQ VQKAAQAAVA SYNMGSNSIY YFRDTHIIKA QSQLVAGIKY FLTMEMGSTD CRKTRVTGDH VDLTTCPLAA GAQQEKLRCD FEVLVVPWQN SSQLLKHNCV QM
    Purity
    > 90 % by SDS - PAGE
    Biological Activity Comment
    The IC50 value is < 10nM. The inhibitory function of Cystatin 6 on protease activity of papain was measured by a fluorometric assay using Z-FR-AMC at pH 7.5 at 25C.
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    Discover our top product CST6 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Bioactivity Validated

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Liquid. In 20  mM Tris-HCl buffer(  pH 8.0) containing 10 % glycerol, 1  mM DTT, 0.1M NaCl.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Target
    CST6 (Cystatin E/M (CST6))
    Alternative Name
    CST6 (CST6 Products)
    Synonyms
    CST6 Protein, 1110017E11Rik Protein, N28197 Protein, ichq Protein, cystatin E/M Protein, CST6 Protein, Cst6 Protein
    Background
    CST6 is a member of the type 2 cystatin family. Some of the members are active cysteine protease inhibitors, while cystatin E/M moderate the inhibition of cathepsin B but is not active against cathepsin C. CST6 is secretable proteins that influence osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and the response to systemic inflammation. Recombinant human CST6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
    Molecular Weight
    15.9 kDa (142aa), confirmed by MALDI-TOF
    NCBI Accession
    NP_001314
    UniProt
    Q15828
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