SIGIRR Protein (AA 1-118) (Fc Tag)
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- Target See all SIGIRR Proteins
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-118
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SIGIRR protein is labelled with Fc Tag.
- Purpose
- SIGIRR (human):Fc (human) (rec.)
- Specificity
- Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1.
- Characteristics
- Protein. Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.06EU/μg purified protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >90 % (SDS-PAGE). SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.
- Purity
- >90 % (SDS-PAGE)
- Endotoxin Level
- <0.06EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product SIGIRR Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- Alternative Name
- SIGIRR (SIGIRR Products)
- Synonyms
- TIR8 Protein, AI256711 Protein, sc:d148 Protein, RGD1306732 Protein, single Ig and TIR domain containing Protein, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Protein, SIGIRR Protein, Sigirr Protein, sigirr Protein
- Background
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Alternate Names/Synonyms: Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule
Product Description: SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.
- Pathways
- Toll-Like Receptors Cascades
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