Liver Arginase Protein (active Mutant)
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- Target See all Liver Arginase (ARG1) Proteins
- Liver Arginase (ARG1) (Arginase, Liver (ARG1))
- Protein Type
- Recombinant
- Protein Characteristics
- active Mutant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Arginase I (human) (rec.) (highly active)
- Specificity
- Full length human arginase I.
- Characteristics
- Protein. Full length human arginase I. Source: E. coli. Liquid. In 10 mM TRIS-HCl, pH 7.5, containing 1 mM beta-mercaptoethanol, 1 mM MnCl2 and 50 % glycerol. Purity: >90 % (SDS-PAGE). Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide (NO) pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.
- Purity
- >90 % (SDS-PAGE)
- Biological Activity Comment
- 1.6 ±0.2U/μg protein. One unit is defined as the amount of enzyme that converts 1μmol of L-arginine to L-ornithine and urea per min. at 37°C, pH 9.5 (according to protocol from R.T. Schimke, et al.; J. Biol. Chem. 238, 1012 (1963)).
- Top Product
- Discover our top product ARG1 Protein
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Arginase, Liver (ARG1) (AA 1-322) protein (GST tag)
ARG1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Arginase, Liver (ARG1) protein (MYC tag,His tag)ARG1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Arginase, Liver (ARG1) (Active) protein (Myc-DYKDDDDK Tag)ARG1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD Active
Arginase, Liver (ARG1) (AA 1-322) protein (His tag)ARG1 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. In 10 mM TRIS-HCl, pH 7.5, containing 1 mM beta-mercaptoethanol, 1 mM MnCl2 and 50 % glycerol.
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- -20 °C,-80 °C
- Storage Comment
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Short Term Storage: -20°C
Long Term Storage: -80°C
Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.
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- Target
- Liver Arginase (ARG1) (Arginase, Liver (ARG1))
- Alternative Name
- Arginase I (ARG1 Products)
- Synonyms
- SI:zC146F4.4 (novel protein with NUDIX domain) Protein, si:ch211-146f4.3 Protein, argi1 Protein, AI Protein, AI256583 Protein, Arg-1 Protein, PGIF Protein, arginase 1 Protein, arginase Protein, Arginase-1 Protein, arginase, liver Protein, L-arginase Protein, arg1 Protein, PGTG_16455 Protein, argi1 Protein, ARG1 Protein, Arg1 Protein
- Background
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Alternate Names/Synonyms: EC 3.5.3.1, ARG1, Arginase 1, Type I Arginase, Liver-type Arginase, L-Arginase
Product Description: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide (NO) pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.
- UniProt
- P05089
- Pathways
- Cellular Response to Molecule of Bacterial Origin
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