ICOS Protein (AA 21-139) (Fc Tag)
-
- Target See all ICOS Proteins
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 21-139
-
Origin
- Human
-
Source
- CHO Cells
- Purification tag / Conjugate
- This ICOS protein is labelled with Fc Tag.
- Purpose
- CD278 [ICOS] (human):Fc (human) (rec.) (non-lytic)
- Specificity
- The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of a mutant human IgG1.
- Characteristics
- Protein. The extracellular domain of human CD278 [ICOS] (aa 21-139) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
- Purity
- >98 % (SDS-PAGE)
- Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- Shows the biological function of the CD278 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
- Top Product
- Discover our top product ICOS Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- 4 °C,-20 °C
- Storage Comment
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
-
- Target
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- Alternative Name
- CD278 [ICOS] (ICOS Products)
- Synonyms
- ICOS Protein, AILIM Protein, CCLP Protein, CRP-1 Protein, H4 Protein, Ly115 Protein, CD278 Protein, CVID1 Protein, Ailim Protein, inducible T-cell costimulator Protein, inducible T cell co-stimulator Protein, inducible T-cell co-stimulator Protein, ICOS Protein, LOC100232284 Protein, Icos Protein
- Background
-
Alternate Names/Synonyms: ICOS, Inducible T Cell Costimulator, CRP1, CD28-related Protein-1, AILIM
Product Description: CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
- NCBI Accession
- NP_036224
- Pathways
- Cancer Immune Checkpoints
-